Mounjaro (Tirzepatide)

Mounjaro is initiated at a dose of 2.5 mg (0.6 ml) by subcutaneous injection once weekly for 4 weeks, increasing the dose by 2.5 mg every 4 weeks to a maximum of 15 mg, with treatment evaluated after 24 weeks for effectiveness. Injections are given in the abdomen, thigh or upper arm, rotating sites to avoid complications.

Store Monjaro in the refrigerator (2-8°C). Do not freeze. Not for use by children under 18 years of age, pregnant or breast-feeding women, and use with caution if you have a history of pancreatitis or severe intestinal problems. Use as directed by your healthcare professional. Read the package leaflet before use.

Tirzepatide, the active ingredient in Mounjaro, works by mimicking the effects of natural hormones in the body that regulate blood sugar levels and appetite. As a dual agonist of GIP (glucose-dependent insulinotropic peptide) and GLP-1 (glucagon-like peptide-1) receptors, it enhances insulin secretion in response to high blood sugar levels, slows gastric emptying, and reduces appetite and food intake, leading to improved blood sugar control and weight loss in adults with type 2 diabetes.

Gastrointestinal problems (nausea, vomiting, diarrhea, constipation), possible low blood sugar (especially when used with other diabetes medications), reactions at the injection site, and possibly others depending on the individual's health condition and other medications being taken.

When using Mounjaro (tirzepatide), important precautions include being alert for severe abdominal pain that could be a sign of pancreatitis, monitoring your blood sugar levels due to the risk of low blood sugar when used with other diabetes medications, reporting any changes in urination that could indicate kidney problems, and seeking immediate medical attention if you have persistent digestive problems such as vomiting or diarrhea. It is also important to tell your doctor about any personal or family history of thyroid cancer, given studies linking medications similar to Mounjaro to thyroid problems in rodents. Be alert for signs of allergic reactions, and if you are pregnant or breastfeeding, talk to your healthcare provider about the potential risks.